Novel monoclonal antibodies against pathogenic Leptospira
نویسندگان
چکیده
Background Leptospirosis is a zoonotic disease caused by pathogenic bacteria belonging to the genus Leptospira and more than 1 million cases occur worldwide annually. Several mammals may carry the agent, and rats are the most important source of human infection in urban settings. The Leptospira surface proteins have an important role during pathogen infection and some of these allow the differentiation between pathogenic and non-pathogenic species. Among these, the LigA and LigB adhesins are surface localized proteins that interact with the proteins of extracellular matrix and fibrinogen. Therefore, antibodies against these targets are useful tools in immunodiagnostic assays.
منابع مشابه
Distribution of Anti-leptospira Antibodies in the Sera of Patients Suspected Leptospirosis
Abstract Background and Objective: Leptospirosis is a zoonosis infectious disease that is prevalent in tropical and subtropical regions and is caused by the pathogenic serovars of leptospires. Hence, we aimed at investigating the prevalence of antibodies against these bacteria in the blood samples of suspected leptospirosis. Material and Methods: the human serum samples (N = 130) were ...
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